Floris P J G Lafeber Selected Research

Joint Diseases (Joint Disease)

7/2021	On-demand treatment with the iron chelator deferasirox is ineffective in preventing blood-induced joint damage in haemophilic mice.
7/2021	Challenges in biomarker research in haemophilic arthropathy.
1/2017	Pathophysiology of hemophilic arthropathy and potential targets for therapy.
8/2015	The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia.
11/2014	Deferasirox limits cartilage damage following haemarthrosis in haemophilic mice.
9/2013	Do radiographic joint damage and disease activity influence functional disability through different mechanisms? Direct and indirect effects of disease activity in established rheumatoid arthritis.
1/2009	The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy.
9/2008	Interleukin-10 protects against blood-induced joint damage.
1/2008	Role of interleukin-7 in degenerative and inflammatory joint diseases.
11/2007	Profiling of endogenous peptides in human synovial fluid by NanoLC-MS: method validation and peptide identification.

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Floris P J G Lafeber Research Topics

Disease

40	Rheumatoid Arthritis 11/2022 - 06/2002
24	Osteoarthritis 12/2021 - 01/2002
20	Inflammation (Inflammations) 11/2020 - 07/2002
10	Joint Diseases (Joint Disease) 07/2021 - 11/2007
8	Pain (Aches) 01/2021 - 01/2011
7	Arthritis (Polyarthritis) 12/2020 - 11/2005
5	Knee Osteoarthritis 01/2021 - 07/2017
4	Synovitis 11/2020 - 06/2005
4	Hemophilia A (Haemophilia) 01/2017 - 02/2013
4	Autoimmune Diseases (Autoimmune Disease) 01/2016 - 10/2006
3	Experimental Arthritis 01/2015 - 09/2010
3	Necrosis 12/2012 - 05/2007
2	Infections 01/2021 - 11/2020
2	Wounds and Injuries (Trauma) 11/2020 - 01/2017
2	Hemorrhage 01/2017 - 02/2003
2	Rheumatic Diseases (Rheumatism) 08/2014 - 01/2008
1	Fibromyalgia (Fibrositis) 01/2021
1	Disease Progression 01/2020
1	Fatigue 12/2017
1	Chronic Disease (Chronic Diseases) 12/2017
1	Vascular Remodeling 01/2017
1	Aneurysm (Aneurysms) 01/2017
1	Hyperalgesia 01/2016
1	Neuralgia (Stump Neuralgia) 01/2016
1	Chronic Pain 01/2016
1	Hyperplasia 08/2015
1	Hemochromatosis (Bronze Diabetes) 08/2015
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 08/2014
1	Body Weight (Weight, Body) 01/2013

Drug/Important Bio-Agent (IBA)

14	Biomarkers (Surrogate Marker)IBA 07/2021 - 11/2007
14	Methotrexate (Mexate)FDA LinkGeneric 01/2021 - 03/2012
12	CytokinesIBA 01/2021 - 07/2002
10	Interleukin-7 (Interleukin 7)IBA 01/2015 - 06/2005
7	Pharmaceutical PreparationsIBA 01/2021 - 02/2013
6	tocilizumab (atlizumab)FDA Link 01/2021 - 12/2017
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 11/2007
5	Biological ProductsIBA 01/2020 - 07/2015
4	Collagen Type II (Type II Collagen)IBA 12/2021 - 01/2009
4	Antirheumatic Agents (DMARD)IBA 01/2021 - 01/2013
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018 - 05/2007
4	GlucocorticoidsIBA 04/2017 - 11/2005
4	IronIBA 01/2017 - 03/2014
4	Thymic Stromal LymphopoietinIBA 01/2016 - 05/2014
4	Interleukin-10 (Interleukin 10)IBA 01/2016 - 04/2003
4	Proteoglycans (Proteoglycan)IBA 01/2015 - 02/2003
4	InterleukinsIBA 01/2015 - 05/2007
3	AntigensIBA 01/2020 - 07/2008
3	Interleukin-4 (Interleukin 4)IBA 01/2016 - 12/2012
3	Prednisone (Sone)FDA LinkGeneric 10/2015 - 03/2012
3	CollagenIBA 01/2013 - 01/2002
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 11/2020
2	ametantrone (HAQ)IBA 12/2020 - 09/2013
2	Folic Acid (Vitamin M)FDA LinkGeneric 12/2020 - 01/2018
2	Peptides (Polypeptides)IBA 01/2019 - 11/2007
2	3-benzoyl dopamine (MBDA)IBA 11/2018 - 10/2012
2	LipidsIBA 12/2016 - 09/2016
2	Cartilage Oligomeric Matrix ProteinIBA 01/2013 - 01/2009
2	InterferonsIBA 12/2012 - 10/2006
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2011 - 01/2006
2	Immunoglobulin G (IgG)IBA 12/2004 - 05/2003
2	Advanced Glycation End ProductsIBA 04/2004 - 01/2002
1	amsonic acid (DAS)IBA 11/2022
1	IL4-IL10 fusion proteinIBA 01/2021
1	Ointments (Pastes)IBA 11/2020
1	cadexomer iodineIBA 11/2020
1	Analgesics (Analgesic Drugs)IBA 11/2020
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 11/2020
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2020
1	Dinoprostone (PGE2)FDA Link 11/2020
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 01/2020
1	Rheumatoid FactorIBA 01/2020
1	AutoantibodiesIBA 01/2020
1	Rituximab (Mabthera)FDA Link 11/2018
1	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 01/2018
1	AlbuminsIBA 01/2018
1	Peptide Hydrolases (Proteases)FDA Link 01/2017
1	Blood Coagulation Factors (Coagulation Factor)IBA 01/2017
1	Matrix Metalloproteinases (MMPs)IBA 01/2017
1	Cathepsin BIBA 01/2017
1	Hyaluronic Acid (Hyaluronan)IBA 05/2016
1	MicroRNAs (MicroRNA)IBA 01/2016
1	Chelating AgentsIBA 11/2014
1	Deferasirox FDA Link 11/2014
1	Immunoglobulin A (IgA)IBA 08/2014
1	ChemokinesIBA 10/2013
1	Factor VIII (Coagulation Factor VIII)IBA 02/2013
1	strontium ranelate (protelos)IBA 02/2013

Therapy/Procedure

11	Therapeutics 07/2021 - 11/2005
3	Knee Replacement Arthroplasty (Total Knee Replacement) 01/2021 - 07/2017
3	Intra-Articular Injections 02/2013 - 09/2012
2	Osteotomy 01/2021 - 01/2021
2	Spinal Injections 01/2021 - 12/2019
2	Aftercare (After-Treatment) 11/2018 - 10/2018
2	Injections 01/2016 - 09/2012
2	Bed Rest (Bedrest) 09/2012 - 11/2005
1	CARE protocol 11/2020
1	Arthroplasty 01/2020
1	Drug Therapy (Chemotherapy) 01/2020
1	Conservative Treatment 07/2017
1	Orthopedic Procedures 01/2017